N-substituted mercaptopropanamide derivative

Abstract

NEW MATERIAL:A compound shown by formula I (R 1 is mercapto or group which is scissored in organism into mercapto; W is H, alkyl or aralkyl; R 2 is aryl, heterocyclic ring or alkyl; X is cycloalkylene, cycloalkylidene, etc.; R 3 is carboxyly, etc.) or a salt thereof. EXAMPLE: 3-[(2-Acetylthiomethyl-3-phenylpropionyl)amino]-5-methyl benzoate. USE: An analgesic showing effects even by oral administration. PREPARATION: A compound shown by formula II is reacted with a compound shown by formula III or a reactive derivative thereof to give a compound shown by formula I. The reaction, for example, is carried out in the presence of a condensation agent such as dicyclohexylcarbodiimide or reacting the reactive derivative of the compound shown by formula III with the compound shown by formula II. COPYRIGHT: (C)1990,JPO&Japio

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